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KMID : 0350519920450020635
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Journal of Catholic Medical College
1992 Volume.45 No. 2 p.635 ~ p.646
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Immunocytochemical Identification of Dopaminergic Neurons and Their Synaptic Organization in the Cat Olfactory Bulb
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Abstract
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Dopamine is now widely accepted as a putative neurotransmitter in the mammalina olfactory bulb, and tyrosine hydroxylase, a rate-limiting enzyme in the biosynthesis of catecholamine, is regarded as a reliable good marker for dopaminergic neuron.
Though
a number of morphological studies on dopaminergic neurons of the olfactory bulb have been done light microscopically in the rat and hamster, ultrastructrual studies to define the synaptic organization of dopaminergic neurons have not been
performed
vet.
This sutdy was conducted in order to identify dopaminergic neurons and to define their synpatic organizations in the olfactory bulb of thecat by the preembedding immunocytochemical method using tyrosine hydroxylase antiserum.
@ES The results were as follows;
@ES 1.Dopaminergic neurons were some periglomerular ceels located in the glomerular layer and a few of tufted cells in the periglomerular and external plexiform layers of the cat olfactory bulb.
2. Processes of dopaminergic periglomerular cells made synapses with axon terminals of the olfactory nerve, dendrites of mitral or tufted cells, and soma and processes of non-dopaminergic periglomerular cells.
3. Dendirtes of dopaminergic tufted cells made synapses with axon terminals of olfactory nerve and processes of non-dopaminergic periglomerular cells in the glomerular layer.
The results demonstrate that dopaminergic periglomerular and tufted cells in the cat olfactory bulb make specific synapses with non-dopaminergic periglomerular cells and tufted o rmitral cells in the glomerular layer, and they might play an
important
role in establishing olfactory informations in the olfactory bulb.
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